- Research Focus: Angiogenesi, Applicazioni terapeutiche, Caratterizzazione funzionale, Caratterizzazione molecolare, Comunicazione intercellulare, Inflammation, Medicina rigenerativa, Oxidative stress, RNA, Sistema immunitario e modulazione
- Regione: Sicilia
- Matrici: Linee cellulari tumorali, Plasma/siero, Piante, Saliva
- Strumentazione: Citometria a flusso, Colture cellulari, Correlative light-electron microscopy, ELISA, Live cell imaging, Mass spectrometry, Microscopia confocale, Polymerase chain reaction (PCR), Proteomica, Scanning electron microscopy (SEM)
- Patologie: Cancro/Tumori, Malattie croniche
Laboratorio di Oncologia cellulare e proteomica
Contatti
UNiversità di Palermo
Via Divisi, 83
Palermo
Via Divisi, 83
Palermo
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Patologie
Malattie croniche, Tumori ematologici, Tumori fegato, Tumori Colon-retto.
Pubblicazioni
1.Urzì O., Gasparro R., Rabienezhad Ganji N., Alessandro R., Raimondo S. Plant-RNA in
Extracellular Vesicles: The Secret of Cross-Kingdom Communication. Membranes (Basel),
Mar 23;12(4):352, 2022.
2. Corrado C., Barreca M.M., Zichitella C., Alessandro R., Conigliaro A. Molecular Mediators
of RNA Loading into Extracellular Vesicles. Cells, Nov 30;10(12):3355, 2021.
3. Pucci M., Raimondo S., Urzì O., Moschetti M., Di Bella M.A., Conigliaro A., Caccamo N.,
La Manna M.P., Fontana S., Alessandro R. Tumor-Derived Small Extracellular Vesicles
Induce Pro-Inflammatory Cytokine Expression and PD-L1 Regulation in M0 Macrophages
via IL-6/STAT3 and TLR4 Signaling Pathways. Int J Mol Sci, Nov 9;22(22):12118, 2021.
4. Fontana S., Mauceri R., Novara M.E., Alessandro R., Campisi G. Protein Cargo of Salivary
Small Extracellular Vesicles as Potential Functional Signature of Oral Squamous Cell
Carcinoma. Int J Mol Sci, Oct 16;22(20):11160, 2021.
5. Santos M.F., Rappa G., Karbanová J., Fontana S., Di Bella M.A., Pope M.P., Parrino B.,
Cascioferro S.M., Vistoli G., Diana P., Cirrincione G., Arena G.O., Woo G., Huang K.,
Huynh T., Moschetti M,, Alessandro R., Corbeil D., Lorico A. Itraconazole inhibits nuclear
delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the
nucleoplasmic reticulum. J Extracell Vesicles, Aug;10(10): e12132, 2021.
6. Raimondo S., Pucci M., Alessandro R., Fontana S. Extracellular Vesicles and Tumor-
Immune Escape: Biological Functions and Clinical Perspectives. Int J Mol Sci,
26;21(7):2286, 2020.
7. Raimondo S., Urzì O., Conigliaro A., Lo Bosco G., Parisi S., Carlisi M., Siragusa S.,
Raimondi L., De Luca A., Giavaresi G., Alessandro R. Extracellular Vesicle microRNAs
Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma.
Cancers (Basel), 14;12(2):449, 2020.
8. Raimondo S., Saieva L., Vicario E., Pucci M., Toscani D., Manno M., Raccosta S., Giuliani
N., Alessandro R. Multiple myeloma-derived exosomes are enriched of amphiregulin
(AREG) and activate the epidermal growth factor pathway in the bone microen.vironment
leading to osteoclastogenesis. J Hematol Oncol, 12(1):2, 2019.
9. Raimondo S., Giavaresi G., Lorico A., Alessandro R. Extracellular Vesicles as Biological
Shuttles for Targeted Therapies. Int J Mol Sci, Apr 15;20(8):1848, 2019.
10. Taverna S., Pucci M., Giallombardo M., Di Bella M.A., Santarpia M., Reclusa P., Gil-Bazo
I., Rolfo C., Alessandro R. Amphiregulin contained in NSCLC-exosomes induces osteoclast
differentiation through the activation of EGFR pathway. Scientific Reports, Jun
9;7(1):3170, 2017.
11. Conigliaro A., Fontana S., Raimondo S., Alessandro R. Exosomes: Nanocarriers of
Biological Messages. Adv Exp Med Biol, 998:23-43, 2017.
12. Taverna S., Fontana S., Monteleone F., Pucci M., Saieva L., De Caro V., Cardinale VG,
Giallombardo M., Vicario E., Rolfo C., Leo GD, Alessandro R. Curcumin modulates
chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via
exosomal miR-21. Oncotarget, May 24;7(21):30420-39, 2015.
13. Conigliaro A., Costa V., Lo Dico A., Saieva L., Buccheri S., Dieli F., Manno M., Raccosta
S., Mancone C., Tripodi M., De Leo G., Alessandro R. CD90+ Liver Cancer Cells Modulate
Endothelial Cell Phenotype through the Release of Exosomes Containing H19 lncRNA.
Molecular Cancer, 14:155, 2015.
14. Raimondo S., Naselli F., Fontana S., Monteleone F., Lo Dico A., Saieva L., Zito G., Flugy
A., Manno M., Di Bella MA., De Leo G., Alessandro R. Citrus limon L.-derived
nanovesicles induce TRAIL-mediated cancer cell death. Oncotarget, 6(23):19514-27, 2015.
15. Schillaci O., Fontana S., Monteleone F., Taverna S., Di Bella M.A., Di Vizio D., Alessandro
R. Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic
cells and increase endothelial permeability: their emerging role in tumor heterogeneity. Sci
Rep Jul, 5;7(1):4711, 2017.
16. Raimondo S., Naselli F., Fontana S., Monteleone F., Lo Dico A., Saieva L., Zito G., Flugy
A., Manno M., Di Bella M.A., De Leo G., Alessandro R. Citrus limon-derived nanovesicles
inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-
mediated cell death. Oncotarget, Aug 14;6(23):19514-27, 2015.
Extracellular Vesicles: The Secret of Cross-Kingdom Communication. Membranes (Basel),
Mar 23;12(4):352, 2022.
2. Corrado C., Barreca M.M., Zichitella C., Alessandro R., Conigliaro A. Molecular Mediators
of RNA Loading into Extracellular Vesicles. Cells, Nov 30;10(12):3355, 2021.
3. Pucci M., Raimondo S., Urzì O., Moschetti M., Di Bella M.A., Conigliaro A., Caccamo N.,
La Manna M.P., Fontana S., Alessandro R. Tumor-Derived Small Extracellular Vesicles
Induce Pro-Inflammatory Cytokine Expression and PD-L1 Regulation in M0 Macrophages
via IL-6/STAT3 and TLR4 Signaling Pathways. Int J Mol Sci, Nov 9;22(22):12118, 2021.
4. Fontana S., Mauceri R., Novara M.E., Alessandro R., Campisi G. Protein Cargo of Salivary
Small Extracellular Vesicles as Potential Functional Signature of Oral Squamous Cell
Carcinoma. Int J Mol Sci, Oct 16;22(20):11160, 2021.
5. Santos M.F., Rappa G., Karbanová J., Fontana S., Di Bella M.A., Pope M.P., Parrino B.,
Cascioferro S.M., Vistoli G., Diana P., Cirrincione G., Arena G.O., Woo G., Huang K.,
Huynh T., Moschetti M,, Alessandro R., Corbeil D., Lorico A. Itraconazole inhibits nuclear
delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the
nucleoplasmic reticulum. J Extracell Vesicles, Aug;10(10): e12132, 2021.
6. Raimondo S., Pucci M., Alessandro R., Fontana S. Extracellular Vesicles and Tumor-
Immune Escape: Biological Functions and Clinical Perspectives. Int J Mol Sci,
26;21(7):2286, 2020.
7. Raimondo S., Urzì O., Conigliaro A., Lo Bosco G., Parisi S., Carlisi M., Siragusa S.,
Raimondi L., De Luca A., Giavaresi G., Alessandro R. Extracellular Vesicle microRNAs
Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma.
Cancers (Basel), 14;12(2):449, 2020.
8. Raimondo S., Saieva L., Vicario E., Pucci M., Toscani D., Manno M., Raccosta S., Giuliani
N., Alessandro R. Multiple myeloma-derived exosomes are enriched of amphiregulin
(AREG) and activate the epidermal growth factor pathway in the bone microen.vironment
leading to osteoclastogenesis. J Hematol Oncol, 12(1):2, 2019.
9. Raimondo S., Giavaresi G., Lorico A., Alessandro R. Extracellular Vesicles as Biological
Shuttles for Targeted Therapies. Int J Mol Sci, Apr 15;20(8):1848, 2019.
10. Taverna S., Pucci M., Giallombardo M., Di Bella M.A., Santarpia M., Reclusa P., Gil-Bazo
I., Rolfo C., Alessandro R. Amphiregulin contained in NSCLC-exosomes induces osteoclast
differentiation through the activation of EGFR pathway. Scientific Reports, Jun
9;7(1):3170, 2017.
11. Conigliaro A., Fontana S., Raimondo S., Alessandro R. Exosomes: Nanocarriers of
Biological Messages. Adv Exp Med Biol, 998:23-43, 2017.
12. Taverna S., Fontana S., Monteleone F., Pucci M., Saieva L., De Caro V., Cardinale VG,
Giallombardo M., Vicario E., Rolfo C., Leo GD, Alessandro R. Curcumin modulates
chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via
exosomal miR-21. Oncotarget, May 24;7(21):30420-39, 2015.
13. Conigliaro A., Costa V., Lo Dico A., Saieva L., Buccheri S., Dieli F., Manno M., Raccosta
S., Mancone C., Tripodi M., De Leo G., Alessandro R. CD90+ Liver Cancer Cells Modulate
Endothelial Cell Phenotype through the Release of Exosomes Containing H19 lncRNA.
Molecular Cancer, 14:155, 2015.
14. Raimondo S., Naselli F., Fontana S., Monteleone F., Lo Dico A., Saieva L., Zito G., Flugy
A., Manno M., Di Bella MA., De Leo G., Alessandro R. Citrus limon L.-derived
nanovesicles induce TRAIL-mediated cancer cell death. Oncotarget, 6(23):19514-27, 2015.
15. Schillaci O., Fontana S., Monteleone F., Taverna S., Di Bella M.A., Di Vizio D., Alessandro
R. Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic
cells and increase endothelial permeability: their emerging role in tumor heterogeneity. Sci
Rep Jul, 5;7(1):4711, 2017.
16. Raimondo S., Naselli F., Fontana S., Monteleone F., Lo Dico A., Saieva L., Zito G., Flugy
A., Manno M., Di Bella M.A., De Leo G., Alessandro R. Citrus limon-derived nanovesicles
inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-
mediated cell death. Oncotarget, Aug 14;6(23):19514-27, 2015.