Research Focus: Biomarcatori, Caratterizzazione molecolare, Comunicazione intercellulare
Regione: Basilicata
Matrici: Plasma/siero
Strumentazione: Citometria a flusso, Colture cellulari, ELISA, Genomica, Microscopia confocale, Nanoparticle tracking analysis, Polymerase chain reaction (PCR), Sequencing, Ultracentrifuge, Western blot
Patologie: Cancro/Tumori



via Padre Pio 1,
Rionero in Vulture (PZ)

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Tumori ematologici, Cancro ai polmoni 


  • Trino S., et al. Acute Myeloid Leukemia Cells Functionally Compromise Hematopoietic Stem/Progenitor Cells Inhibiting Normal Hematopoiesis Through the Release of Extracellular Vesicles. Front Oncol. 2022 Mar 16;12:824562. doi: 10.3389/fonc.2022.824562.
  • Laurenzana I., et al. Multiple Myeloma-Derived Extracellular Vesicles Impair Normal Hematopoiesis by Acting on Hematopoietic Stem and Progenitor Cells. Front Med (Lausanne). 2021 Dec 16;8:793040. doi: 10.3389/fmed.2021.793040.
  • Laurenzana I., et al. Analysis of Amount, Size, Protein Phenotype and Molecular Content of Circulating Extracellular Vesicles Identifies New Biomarkers in Multiple Myeloma. Int J Nanomedicine. 2021 May 7;16:3141-3160. doi: 10.2147/IJN.S303391.
  • Trino S. et al. Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy. Leukemia. 2021 Mar;35(3):661-678. doi: 10.1038/s41375-020-01104-1.
  • De Luca L., et al. An update on extracellular vesicles in multiple myeloma: a focus on their role in cell-to-cell cross-talk and as potential liquid biopsy biomarkers. Expert Rev Mol Diagn. 2019 Mar;19(3):249-258. doi: 10.1080/14737159.2019.1583103.
  • Laurenzana I., et al. Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies. Stem Cells Int. 2018 May 27;2018:9863194. doi: 10.1155/2018/9863194.
  • Trino S., et al. MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia. Int J Mol Sci. 2018 Feb 3;19(2):460. doi: 10.3390/ijms19020460.
  • Caivano E., et al. Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy. Int J Mol Sci. 2017 Jun 2;18(6):1183. doi: 10.3390/ijms18061183.
  • De Luca L., et al. Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia. Leuk Lymphoma. 2017 Jun;58(6):1424-1432. doi: 10.1080/10428194.2016.1243790.
  • De Luca L., et al. Mesenchymal Stem Cell Derived Extracellular Vesicles: A Role in Hematopoietic Transplantation? Int J Mol Sci. 2017 May 9;18(5):1022. doi: 10.3390/ijms18051022.
  • Caivano A., et al. MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report. Cell Oncol (Dordr). 2017 Feb;40(1):97-103. doi: 10.1007/s13402-016-0300-x.
  • De Luca L., et al. MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation. Oncotarget. 2016 Feb 9;7(6):6676-92. doi: 10.18632/oncotarget.6791.
  • Caivano A., et al. High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders. Tumour Biol. 2015 Dec;36(12):9739-52. doi: 10.1007/s13277-015-3741-3.

Consorzi di ricerca